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ea0063p309 | Reproductive Endocrinology 1 | ECE2019

Ano-genital distance in children born of mothers with polycystic ovary syndrome – Odense Child Cohort

Glintborg Dorte , Jensen Richard Christian , Schmedes Anne Vibeke , Brandslund Ivan , Kyhl Henriette Boye , Nielsen Tina Kold , Andersen Marianne Skovsager

Background: Higher testosterone levels during pregnancy in women with polycystic ovary syndrome (PCOS) could be associated with longer offspring ano-genital distance (AGD).Aims: To compare AGD between offspring of mothers with PCOS and controls and to determine possible associations between maternal 3rd trimester testosterone levels and offspring AGD at three months of age.Methods: The study was part of the prospective s...

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ea0099p361 | Reproductive and Developmental Endocrinology | ECE2024

Prenatal testosterone exposure and offspring body composition at 7 years-of-age. odense child cohort

Palm Camilla , Glintborg Dorte , Grontved Anders , Jensen Dorte , Hansen Freja , Jorgensen Jan , Christesen Henrik , Jensen Tina , Andersen Marianne

Background: Maternal free testosterone (FT) increases during 3rd trimester pregnancy and FT levels are higher in women with polycystic ovary syndrome (PCOS) compared to controls. Fetal exposure to maternal FT during 3rd trimester was associated with lower weight, length and shorter abdominal circumference at birth, in boys. Furthermore, lower birth weight has been related to higher abdominal fat mass in young children.Aim: To examine associations between...

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ea0090rc9.5 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Higher maternal cortisol associated with lower blood pressure in offspring from 3 months to 5 years of age in the odense child cohort

Al-Jorani Hajir , Christian Jensen Richard , Jonasson Mikaela , Birukov Anna , Schmedes Anne Vibeke , Christesen Henrik Thybo , Dreyer Anja Fenger , Jensen Tina Kold , Glintborg Dorte , Jensen Boye Lagerbon , Andersen Marianne

Background: Synthetic glucocorticoid exposure in late pregnancy may be associated with higher blood pressure in offspring. We hypothesized that endogenous cortisol in pregnancy relates to offspring blood pressure (OBP).Objective: To investigate associations between maternal cortisol status in 3rd trimester pregnancy and OBP.Methods: We included 1,317 mother-child pairs from Odense Child Cohort (OCC), an observational prospective co...

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ea0090ep23 | Adrenal and Cardiovascular Endocrinology | ECE2023

REPLACE: Effect of hydrocortisone and placebo in patients with partial adrenal insufficiency after cessation of glucocorticoid treatment; A study protocol for a multi-centre, randomised, double-blinded, placebo-controlled clinical trial

Dreyer Anja Fenger , Borresen Stina Willemoes , Hansen Simon Boggild , Al-Jorani Hajir , Bislev Lise Sofie , Boesen Victor Brun , Christensen Louise Lehmann , Glintborg Dorte , Jensen Richard Christian , Jorgensen Nanna Thurmann , Klose Marianne , Lund Marie Louise , Stankovic Jelena , Tei Randi , Watt Torquil , Feldt-Rasmussen Ulla , Jorgensen Jens Otto , Andersen Marianne

Background: Glucocorticoid (GC) formulations are widely used as anti-inflammatory treatment, and synthetic GC, e.g. prednisolone, is the cornerstone treatment of polymyalgia rheumatic (PMR) and giant cell arteritis (GCA). Long-term pharmacological GC treatment may induce adrenal insufficiency (GIA). Adrenal function is, however, not routinely assessed after discontinuation of long-term GC treatment, and it is unknown, if hydrocortisone replacement is beneficial. This study aim...

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ea0099p12 | Adrenal and Cardiovascular Endocrinology | ECE2024

How to assess adrenal function during low dose prednisolone treatment – impact of a 1- vs 2-day prednisolone pause before the ACTH test: Results from the Double Edge-Rescue Study

Willemoes Borresen Stina , Hansen SimonBoggild , Al-Jorani Hajir , Bislev LiseSofie , Boesen VictorBrun , Christensen LouiseLehmann , Feldt-Rasmussen Ulla , Dreyer AnjaFenger , Glintborg Dorte , Jensen RichardChristian , Jorgensen NannaThurmann , Lund MarieLouise , Okutan Sema , Stankovic Jelena , Tei Randi , Hetland MereteLund , Locht Henning , Hauge Ellen , Keller Kresten , Just SorenAndreas , Voss Anne , Sorensen Henrik Toft , Stewart Paul M. , Jorgensen JensOtto , Andersen Marianne , Klose Marianne

Background: Correctly identifying glucocorticoid-induced adrenal insufficiency in patients tapering prednisolone treatment to ≤5 mg daily is crucial. Pausing prednisolone before an ACTH-test is standard, yet the optimal pause duration is uncertain.Aim: To determine the outcome of an ACTH-test after 1 vs 2 days prednisolone pause before the test.Methods: Baseline data from an ongoing randomised clinical trial (EudraCT:20...

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Endocrine Abstracts

Ano-genital distance in children born of mothers with polycystic ovary syndrome – Odense Child Cohort

Prenatal testosterone exposure and offspring body composition at 7 years-of-age. odense child cohort

Higher maternal cortisol associated with lower blood pressure in offspring from 3 months to 5 years of age in the odense child cohort

REPLACE: Effect of hydrocortisone and placebo in patients with partial adrenal insufficiency after cessation of glucocorticoid treatment; A study protocol for a multi-centre, randomised, double-blinded, placebo-controlled clinical trial

How to assess adrenal function during low dose prednisolone treatment – impact of a 1- vs 2-day prednisolone pause before the ACTH test: Results from the Double Edge-Rescue Study

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